Assessment of glomerular filtration rate in normally hydrated and dehydrated dromedary camel by plasma exogenous creatinine clearance test
| Autor: | Mohamed Oukessou, Bernard Faye, Asma Kamili, Hervé P. Lefebvre, Mohammed Bengoumi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
L51 - Physiologie animale - Nutrition
medicine.medical_specialty Dromadaire Renal function Applied Microbiology and Biotechnology chemistry.chemical_compound Physiologie de la nutrition Bolus (medicine) Pharmacokinetics Internal medicine Blood plasma Privation d'eau medicine Déshydratation Mean corpuscular volume Creatinine medicine.diagnostic_test Chemistry Blood proteins Endocrinology Blood chemistry Physiologie animale Animal Science and Zoology Rein Agronomy and Crop Science Filtration Food Science |
| Zdroj: | Emirates Journal of Food and Agriculture |
| Popis: | The main objective of this study was to assess glomerular filtration rate (GFR) in the camels (Camelus dromedarius) under free water access and dehydration conditions (after a 34 days-period of water deprivation) using plasma exogenous creatinine clearance without urine collection. Trials were carried out on six nonpregnant, non-lactating and healthy female camels. Creatinine was administered as an IV bolus at a dose of 16 mg/kg body weight. Blood samples were collected at predetermined times over 24 h post-injection. Plasma creatinine concentration was analysed using Jaffé method. Creatinine clearance was calculated by pharmacokinetic analysis using a non-compartmental approach. Water deprivation induced a significant 15%- decrease in body weight but did not affect haematocrit and total plasma proteins. Mean corpuscular volume increased and red blood cells number decreased in dehydrated conditions. Dehydration produced a significant 30%-increase in plasma creatinine and mean residence time and a significant 20%-decrease in GFR. In conclusion, water deprivation decreased glomerular filtration and plasma exogenous creatinine clearance test could be used as a practical method for GFR assessment in dromedary camel in field conditions. |
| Databáze: | OpenAIRE |
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