Major Racial Differences in Coronary Constrictor Response Between Japanese and Caucasians With Recent Myocardial Infarction
| Autor: | Attilio Maseri, John F. Beltrame, Tommaso Sanna, Ryuichi Hattori, Domenico Cianflone, Shigetake Sasayama, M. L. Finocchiaro, Masatoshi Fujita, Christian Pristipino, Rocco Mongiardo |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Arteriosclerosis Myocardial Infarction Coronary Vasospasm Vasodilation White People Angina Asian People Japan Physiology (medical) Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Aged business.industry Incidence Angiography Vasospasm Middle Aged medicine.disease Acetylcholine Vasomotor System Coronary arteries medicine.anatomical_structure Italy Vasoconstriction Coronary occlusion Coronary vasospasm Cardiology Myocardial infarction complications Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 101:1102-1108 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background —Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial. Methods and Results —The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non–infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography. Japanese patients had much lower cholesterol levels than Caucasians (183±59 versus 247±53 mg/dL, P P P P Conclusions —Soon after AMI, Japanese patients exhibited a 3-fold-greater incidence of spasm and greater vasoconstriction of nonspastic segments after acetylcholine than Caucasians. The causes of such differences warrant further investigation because they may have relevant pathophysiological and therapeutic implications. |
| Databáze: | OpenAIRE |
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