Intravitreal dexamethasone implant in patients with persistent macular edema of variable etiologies

Autor:	Zohar Habot-Wilner, Nir Sorkin, Michaela Goldstein, Anat Loewenstein
Rok vydání:	2014
Předmět:	Adult Male medicine.medical_specialty genetic structures education Visual Acuity Dexamethasone Macular Edema Text mining medicine Humans In patient Macular edema Glucocorticoids Intraocular Pressure Aged Retrospective Studies Aged 80 and over Drug Implants business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease eye diseases Sensory Systems Surgery Ophthalmology Drug delivery Intravitreal Injections Etiology Female sense organs Implant business hormones hormone substitutes and hormone antagonists medicine.drug Follow-Up Studies
Zdroj:	Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 232(2)
ISSN:	1423-0267
Popis:	Purpose: To examine the effect of an intravitreal dexamethasone drug delivery system (DEX-DDS) in the treatment of persistent cystoid macular edema (CME) of different etiologies. Methods: Thirty-seven eyes with persistent CME were treated with DEX-DDS and analyzed for changes in best-corrected visual acuity (BCVA) and optical coherence tomography. Eyes were categorized into three groups: diabetic macular edema (DME, n = 14), vein occlusion (n = 15) and uveitis (n = 7). Results: The mean follow-up was 22 ± 6.9 weeks. BCVA improved from 0.62 ± 0.38 to 0.35 ± 0.29 logMAR (p < 0.0001). Central macular thickness decreased by 184 ± 246 µm from baseline (p < 0.0001). In eyes where CME resolved and recurred, the average CME-free period was 11 weeks. The uveitis group showed faster CME resolution (2 weeks) and a longer CME-free period (20 weeks). Similar efficacy was shown for repeat DEX-DDS injections. The safety profile was good. Conclusion: DEX-DDS is beneficial in the treatment of persistent CME. In cases of uveitis, CME resolution is rapid, resulting in the longest effect duration, when compared with other CME etiologies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5428195afde93116766522ff275c2ea1 https://pubmed.ncbi.nlm.nih.gov/24942067 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.