Brain MRI Findings in Patients with Initial Cerebral Thrombosis and the Relationship between Incidental Findings, Aging and Dementia
| Autor: | Masaru Takasaki, Toshihiko Iwamoto, Masanobu Uno, Toyohiro Okada, Kiyotaka Yanagawa, Kimikazu Ogawa |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Internal capsule Lesion Atrophy Risk Factors Internal medicine medicine Humans Dementia Stroke Aged Aged 80 and over medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Intracranial Embolism and Thrombosis Middle Aged medicine.disease Magnetic Resonance Imaging Thrombosis Hyperintensity Multivariate Analysis Cardiology Female Geriatrics and Gerontology medicine.symptom business |
| Zdroj: | Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 31:879-888 |
| ISSN: | 0300-9173 |
| DOI: | 10.3143/geriatrics.31.879 |
| Popis: | To estimate the relationship between aging, dementia and changes observed on magnetic resonance imaging (MRI) seen in elderly patients with cerebral thrombosis, MRI findings in 103 patients with an initial stroke event (thrombosis group) were compared with those of 37 patients with hypertension/diabetes (high risk group) and 78 patients without those disorders (low risk group). In addition to the causative lesions in the thrombosis group, periventricular hyperintensities (PVH), spotty lesions (SL), silent infarctions (SI), ventricular dilatation (VD), and cortical atrophy (CA) were analyzed in these groups. Infarctions located in the internal capsule/corona radiata were the most frequent causative lesion. Compared to the low risk group, a high incidence of patchy/diffuse PVH, SI, and severe CA was seen in both the thrombosis group and the high risk group. Widespread PVH and multiple SL increased with age in the thrombosis group, while severe CA was seen in each group. SI and VD tended to increase after age 60, though they were not significant. Dementia, diagnosed in 40 out of 78 patients, increased with age. Multivariate analysis revealed the degree of the effects of MRI findings on dementia to be marked in PVH, brain atrophy, causative lesions, and SL, in that order. These results indicated that diffuse PVH and brain atrophy, developing with age, promoted dementia in the elderly with vascular lesions. Moreover, they suggested that a variety of silent brain lesions recognized on MRI other than infarction can affect symptoms in the elderly. |
| Databáze: | OpenAIRE |
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