RSK2 signaling in brain habenula contributes to place aversion learning
| Autor: | Katia Befort, André Hanauer, Brigitte L. Kieffer, Jean-Marie Garnier, Solange Pannetier, Pascale Koebel, Emmanuel Darcq, Carolina Del Boca, Anne-Sophie Kirstetter |
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| Rok vydání: | 2011 |
| Předmět: |
MAPK/ERK pathway
Cognitive Neuroscience Context (language use) Transfection Brief Communication Ribosomal Protein S6 Kinases 90-kDa Mice Cellular and Molecular Neuroscience Antimanic Agents Chlorocebus aethiops Avoidance Learning Animals RNA Small Interfering Analysis of Variance Habenula Gene knockdown Cognition Luminescent Proteins Neuropsychology and Physiological Psychology COS Cells Knockout mouse Conditioning Operant Signal transduction Aversive Stimulus Lithium Chloride Psychology Neuroscience Signal Transduction |
| Zdroj: | Learning & Memory. 18:574-578 |
| ISSN: | 1549-5485 |
| Popis: | RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus with context in a lithium-induced conditioned place aversion task requiring both high-order cognition and emotional processing. Virally mediated shRNA-RSK2 knockdown in the habenula, whose involvement in cognition is receiving increasing attention, also ablated contextual conditioning. RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning. |
| Databáze: | OpenAIRE |
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