Uptake and Release of a Multipurpose Solution Biocide (MAP-D) From Hydrogel and Silicone Hydrogel Contact Lenses Using a Radiolabel Methodology
| Autor: | Alan Yee, Miriam Heynen, Vivian Wing-Sheung Chan, Chau-Minh Phan, Lyndon Jones |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Biocide Propylamines Silicones Lotrafilcon B Hydrogels Silicone hydrogel Daily wear Phosphate Contact Lenses Hydrophilic Hydrogel Polyethylene Glycol Dimethacrylate Highly sensitive 03 medical and health sciences Ophthalmology chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine CLs upper limits chemistry 030221 ophthalmology & optometry Humans Myristamidopropyl dimethylamine Nuclear chemistry Disinfectants |
| Zdroj: | Eyecontact lens. 47(5) |
| ISSN: | 1542-233X |
| Popis: | PURPOSE The purpose of this study was to evaluate the uptake and release of radiolabelled myristamidopropyl dimethylamine (MAP-D) on reusable daily wear contact lenses (CLs) over 7 days. METHODS Three silicone hydrogel (SH) CL materials (lotrafilcon B, balafilcon A, senofilcon A) and two conventional hydrogel (CH) materials (etafilcon A, omafilcon A) were tested. A short-term (experiment 1, N=4) and a longer-term (experiment 2, N=3) study was conducted. In experiment 1, the CLs were incubated in 2 mL of phosphate buffered solution (PBS) containing 14C MAP-D (5 μg/mL) for 8 hrs. The release of 14C MAP-D was measured at t=0.25, 0.5, 1, 2, 4, 8, and 24 hr in PBS. In experiment 2, the CLs were incubated in the 14C MAP-D solution for 8 hrs followed by a 16-hr release in PBS. This cycle was repeated daily for 7 days. At the end of both experiments, lenses were extracted to determine the total uptake of MAP-D. The radioactivity was measured using a beta scintillation counter. RESULTS In experiment 1, all three SH lenses sorbed similar amounts of MAP-D (P=0.99), all of which were higher than the two CH materials (P |
| Databáze: | OpenAIRE |
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