T cell proliferative responses against human papillomavirus type 16 E7 oncoprotein are most prominent in cervical intraepithelial neoplasia patients with a persistent viral infection
| Autor: | A. J. Remmink, M. J. Stukart, Theo J.M. Helmerhorst, Hetty J. Bontkes, J. M. M. Walboomers, T. D. De Gruijl, C. J. L. M. Meijer, R.J. Scheper, René H.M. Verheijen |
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| Přispěvatelé: | Medical oncology laboratory, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Laboratory Medicine, AGEM - Endocrinology, metabolism and nutrition, Obstetrics and gynaecology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, AII - Cancer immunology, Pathology |
| Rok vydání: | 1996 |
| Předmět: |
Adult
T cell Papillomavirus E7 Proteins Recombinant Fusion Proteins T-Lymphocytes Molecular Sequence Data Uterine Cervical Neoplasms Biology Cervical intraepithelial neoplasia Viral infection Virology Virus latency medicine Humans In patient Amino Acid Sequence Human papillomavirus Antigens Viral Papillomaviridae Cells Cultured Binding Sites Papillomavirus Infections virus diseases Oncogene Proteins Viral Middle Aged medicine.disease Uterine Cervical Dysplasia Koilocyte female genital diseases and pregnancy complications Virus Latency Tumor Virus Infections medicine.anatomical_structure Immunology Female Cell Division Follow-Up Studies |
| Zdroj: | Journal of General Virology, 77 ( Pt 9), 2183-91. Society for General Microbiology de Gruijl, T D, Bontkes, H J, Stukart, M J, Walboomers, J M, Remmink, A J, Verheijen, R H, Helmerhorst, T J, Meijer, C J & Scheper, R J 1996, ' T cell proliferative responses against human papillomavirus type 16 E7 oncoprotein are most prominent in cervical intraepithelial neoplasia patients with a persistent viral infection ', Journal of General Virology, vol. 77 ( Pt 9), pp. 2183-91 . https://doi.org/10.1099/0022-1317-77-9-2183 |
| ISSN: | 0022-1317 |
| DOI: | 10.1099/0022-1317-77-9-2183 |
| Popis: | T cell proliferative responses against human papillomavirus type 16 (HPV-16) E7 protein were studied in relation to HPV status over time in 51 women originally diagnosed with abnormal cervical cytology and participating in a follow-up study. HPV-16-positive patients were grouped as having either a persistent, a cleared or a fluctuating HPV-16 infection as determined by PCR in consecutive cervical smears up until the moment of testing. Positive proliferative responses against HPV-16 E7 were found in 15/26 patients with a persistent, cleared or fluctuating HPV-16 infection (57.7%). In contrast, 0/15 patients who had been typed HPV-negative during follow-up showed positive responses (P = 0.0005). Further analysis showed positive responses to be more frequent in patients with persistent HPV-16 infections and stable or progressing cervical lesions (8/9 patients reactive, 88.9%) as compared to patients with cleared or fluctuating HPV-16 infections and stable or regressing cervical lesions (7/17, 41.1%, P = 0.04). The relatively strong T cell proliferative responses against HPV-16 E7 observed in patients with a persistent HPV-16 infection and progressive cervical lesions indicate that the effectivity of such responses cannot be predicted and apparently depends on additional factors. |
| Databáze: | OpenAIRE |
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