Comparison of accelerated T1-weighted whole-brain structural-imaging protocols
| Autor: | Tobias Kober, Bénédicte Maréchal, Denise A. Reyes, Matt A. Bernstein, Jean-Philippe Thiran, Reto Meuli, Kaely Thostenson, Thorsten Feiweier, Alexis Roche, Stephan Kannengiesser, Tony Stoecker, Daniel Brenner, Pavel Falkovskiy, Gunnar Krueger |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Computer science Image quality Cognitive Neuroscience Brain tissue Signal-To-Noise Ratio 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult methods [Magnetic Resonance Imaging] 0302 clinical medicine Imaging Three-Dimensional medicine High spatial resolution T1 weighted Leverage (statistics) Humans Segmentation ddc:610 Simulation medicine.diagnostic_test business.industry Brain Reproducibility of Results Magnetic resonance imaging Pattern recognition Magnetic Resonance Imaging Benchmarking Neurology Female Artificial intelligence Parallel imaging business Artifacts anatomy & histology [Brain] Structural imaging 030217 neurology & neurosurgery methods [Imaging Three-Dimensional] |
| Zdroj: | NeuroImage 124(Pt A), 157-167 (2016). doi:10.1016/j.neuroimage.2015.08.026 |
| ISSN: | 1095-9572 |
| Popis: | Imaging in neuroscience, clinical research and pharmaceutical trials often employs the 3D magnetisation-prepared rapid gradient-echo (MPRAGE) sequence to obtain structural T1-weighted images with high spatial resolution of the human brain. Typical research and clinical routine MPRAGE protocols with similar to 1 mm isotropic resolution require data acquisition time in the range of 5-10 min and often use only moderate two-fold acceleration factor for parallel imaging. Recent advances in MRI hardware and acquisition methodology promise improved leverage of the MR signal and more benign artefact properties in particular when employing increased acceleration factors in clinical routine and research. In this study, we examined four variants of a four-fold-accelerated MPRAGE protocol (2D-GRAPPA, CAIPIRINHA, CAIPIRINHA elliptical, and segmented MPRAGE) and compared clinical readings, basic image quality metrics (SNR, CNR), and automated brain tissue segmentation for morphological assessments of brain structures. The results were benchmarked against a widely-used two-fold-accelerated 3T ADNI MPRAGE protocol that served as reference in this study. 22 healthy subjects (age = 20-44 yrs.) were imaged with all MPRAGE variants in a single session. An experienced reader rated all images of clinically useful image quality. CAIPIRINHA MPRAGE scans were perceived on average to be of identical value for reading as the reference ADNI-2 protocol. SNR and CNR measurements exhibited the theoretically expected performance at the four-fold acceleration. The results of this study demonstrate that the four-fold accelerated protocols introduce systematic biases in the segmentation results of some brain structures compared to the reference ADNI-2 protocol. Furthermore, results suggest that the increased noise levels in the accelerated protocols play an important role in introducing these biases, at least under the present study conditions. (C) 2015 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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