Production of Pyrogenic Exotoxin by Groups of Streptococci: Association with Group A
| Autor: | K M Bettin, Patrick M. Schlievert, Dennis W. Watson |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Hemagglutination Inhibition Tests
Streptococcus pyogenes Erythrogenic toxin Exotoxins Biology medicine.disease_cause Group A Streptococcus agalactiae Microbiology Rheumatic Diseases medicine Animals Humans Immunology and Allergy Nephritis Pyrogens Streptococcus Ouchterlony double immunodiffusion Shock Septic Immunodiffusion Infectious Diseases Passive hemagglutination Rabbits Cardiomyopathies Exotoxin |
| Zdroj: | Journal of Infectious Diseases. 140:676-681 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Several groups of streptococci were tested for production of pyrogenic exotoxins (SPE) with Ouchterlony immunodiffusion, a newly developed passive hemagglutination inhibition assay, and an assay for pyrogenicity and capacity to enhance lethal endotoxin shock. With use of these assays, 68 (91%) of 75 group A streptococcal strains were positive for one or more of SPE types A, B, and C; seven were negative for both the known SPE types and antigenically unrelated pyrogenic exotoxins. Group A strains producing both SPE B and C were the most common, and strains producing A alone or AB and AC together were the least common. All of 11 rheumatogenic group A streptococci elaborated SPE C either alone or together with one or both of SPE types A and B. The 10 nephritogenic strains tested were positive for SPE B; five were positive for B alone. In contrast to group A streptococci, non-group A strains (41 tested) did not produce the known SPE types, and 19 of 19 tested were negative for antigenically unrelated pyrogenic exotoxins. Group A strains from Holland, India, and Japan also elaborated SPE. Several group A streptococci used widely in laboratory experiments were tested for SPE types produced. Three antigenically unrelated group A streptococcal pyrogenic exotoxins (SPE), designated types |
| Databáze: | OpenAIRE |
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