Gut microbiota influence tumor development and Alter interactions with the human immune system
| Autor: | Junting Yan, Xinhui Wang, Minghua Wu, Yanshan Ge, Kasimujiang Aximujiang, Yali Guo, Aliya Abuduwaili, Jie Yan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Inflammation Review Gut microbiota Gut flora medicine.disease_cause lcsh:RC254-282 digestive system Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Microbiome biology digestive oral and skin physiology Immune dysregulation lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens biology.organism_classification Gut-brain/liver/lung axis Metabolism 030104 developmental biology Oncology 030220 oncology & carcinogenesis Immunology medicine.symptom Carcinogenesis |
| Zdroj: | Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-9 (2021) Journal of Experimental & Clinical Cancer Research : CR |
| ISSN: | 1756-9966 |
| Popis: | Recent scientific advances have greatly enhanced our understanding of the complex link between the gut microbiome and cancer. Gut dysbiosis is an imbalance between commensal and pathogenic bacteria and the production of microbial antigens and metabolites. The immune system and the gut microbiome interact to maintain homeostasis of the gut, and alterations in the microbiome composition lead to immune dysregulation, promoting chronic inflammation and development of tumors. Gut microorganisms and their toxic metabolites may migrate to other parts of the body via the circulatory system, causing an imbalance in the physiological status of the host and secretion of various neuroactive molecules through the gut-brain axis, gut-hepatic axis, and gut-lung axis to affect inflammation and tumorigenesis in specific organs. Thus, gut microbiota can be used as a tumor marker and may provide new insights into the pathogenesis of malignant tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink