Progression of Alzheimer’s Disease by Self-Reported Cancer History in the Alzheimer’s Disease Neuroimaging Initiative
| Autor: | Lon S. Schneider, Gary Cutter, Mackenzie E. Fowler, Kristen L. Triebel, Richard E. Kennedy |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Neuroimaging Disease Article 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Neoplasms Internal medicine medicine Humans Longitudinal Studies Aged Aged 80 and over business.industry Proportional hazards model General Neuroscience Cancer General Medicine Middle Aged medicine.disease Clinical trial Psychiatry and Mental health Clinical Psychology 030104 developmental biology Disease Progression Female Observational study Self Report Geriatrics and Gerontology Skin cancer business 030217 neurology & neurosurgery Alzheimer's Disease Neuroimaging Initiative |
| Zdroj: | J Alzheimers Dis |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background Cross-sectional studies suggest self-reported cancer history is associated with decreased risk of Alzheimer's disease (AD). However, little is known about how self-reported cancer affects longitudinal AD progression, the primary outcome in clinical trials and observational studies. Objective To determine self-reported cancer history's effect on longitudinal AD progression in an observational study. Methods We utilized data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to evaluate progression to AD by self-reported all-cancer, breast, prostate, colorectal, or non-melanoma skin cancer history. Linear mixed effects models were used to examine baseline differences and rates of progression on the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) by self-reported cancer history. Age at AD onset was examined using consensus clinical diagnoses with Cox proportional hazards regression. Results Among 1,271 participants, models revealed no significant differences in progression over time but did reveal significantly lower baseline ADAS-Cog score, indicating better cognition at a given age in those with self-reported cancer history. Cox models indicated those with self-reported cancer history had significantly later age of AD onset (HR: 0.67, 95% CI: 0.53-0.85) after adjustment for covariates. Conclusion Participants with self-reported cancer history entered ADNI with better cognition and later age of AD onset, but progressed similarly to participants without such history, indicating differences in AD between those with and without self-reported cancer history emerge early in the disease course. Such differences in longitudinal progression by self-reported cancer history could affect AD trials and observational studies, given the current focus on early disease course. Further investigation is warranted with detailed longitudinal assessment of cancer and AD. |
| Databáze: | OpenAIRE |
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