A systematic review: the current status of carbapenem resistance in East Africa

Autor: Francis Ejobi, Dennis K. Byarugaba, Kenneth Ssekatawa, Edward Wampande
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Acinetobacter baumannii
Veterinary medicine
Klebsiella pneumoniae
Carbapenem resistance
030106 microbiology
lcsh:Medicine
Microbial Sensitivity Tests
medicine.disease_cause
General Biochemistry
Genetics and Molecular Biology
beta-Lactamases
03 medical and health sciences
0302 clinical medicine
Drug Resistance
Bacterial
medicine
East africa
Escherichia coli
polycyclic compounds
Humans
030212 general & internal medicine
lcsh:Science (General)
lcsh:QH301-705.5
biology
Molecular epidemiology
Pseudomonas aeruginosa
business.industry
Incidence (epidemiology)
lcsh:R
General Medicine
Africa
Eastern
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
bacterial infections and mycoses
Proteus mirabilis
East Africa
Anti-Bacterial Agents
Research Note
Carbapenems
lcsh:Biology (General)
bacteria
business
lcsh:Q1-390
Zdroj: BMC Research Notes, Vol 11, Iss 1, Pp 1-9 (2018)
BMC Research Notes
ISSN: 1756-0500
DOI: 10.1186/s13104-018-3738-2
Popis: Objective In this systematic review, we present the molecular epidemiology and knowledge gaps of the carbapenem resistance in East Africa as well as the future probable research interventions that can be used to address the emergence of carbapenem resistance in the region. Results The 17 articles which presented concrete information about the prevalence of carbapenem resistance in East Africa were reviewed. Tanzania exhibited the highest level of carbapenem resistance at 35% while DRC had the lowest level at 0.96%. Uganda was the only country with studies documenting CR obtained amongst hospital environment isolates with incidence ranging from 21% in Pseudomonas aeruginosa to 55% in Acinetobacter baumannii. Carbapenem resistance was more exhibited in A. baumannii (23%), followed by P. aeruginosa (17%), Klebsiella pneumoniae (15%), Proteus mirabilis (14%) and Escherichia coli (12%) mainly isolated from respiratory tract, blood, urine and wound/pus. The regional genetic determinants of carbapenem resistance detected were blaIMP, blaVIM-1 blaSPM-l, blaNDM-1, blaOXA-23 blaOXA-24, blaOXA-58 and blaKPC. Electronic supplementary material The online version of this article (10.1186/s13104-018-3738-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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