Gene drives to fight malaria: current state and future directions

Autor: Andrew Hammond, Roberto Galizi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Mosquito Control
POPULATION REPLACEMENT
MEIOTIC DRIVE
Psychological intervention
Q1
0302 clinical medicine
SEX-RATIO
Public
Environmental & Occupational Health
HOMING ENDONUCLEASE GENES
NUCLEASES
Vector control
Expediting
General Medicine
Mosquito control
Infectious Diseases
Risk analysis (engineering)
CRISPR
Life Sciences & Biomedicine
Warrant
malaria
mosquito
Microbiology
03 medical and health sciences
Tropical Medicine
parasitic diseases
Disease Transmission
Infectious
medicine
genome editing
Animals
Humans
PEST POPULATIONS
Science & Technology
HUMAN-CELLS
Gene Drive Technology
Public Health
Environmental and Occupational Health
Gene drive
medicine.disease
R1
EFFECT SELFISH GENES
030104 developmental biology
Commentary
Parasitology
Business
genetic vector control
MOSQUITO ANOPHELES-STEPHENSI
SYSTEM
030217 neurology & neurosurgery
Malaria
ISSN: 2047-7732
Popis: Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate cost-effective interventions that benefit society without obvious bias related to wealth, age or education. Their species-specific design offers the potential to reduce environmental risks and aim to be compatible and complementary with other control strategies, potentially expediting the elimination and eradication of malaria. A number of strategies have been proposed for gene-drive based control of the malaria mosquito and recent demonstrations have shown proof-of-principle in the laboratory. Though several technical, ethical and regulatory challenges remain, none appear insurmountable if research continues in a step-wise and open manner.
Databáze: OpenAIRE
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