Lack of negative inotropic effects of the new calcium antagonist Ro 40-5967 in patients with stable angina pectoris
| Autor: | R. Schmitt, S. Braat, E. E. Van Der Wall, C. H. Kleinbloesem, C. J. Kraaij, G. Prager, A. Gassner, H. Pozenel, Mireille C.M. Portegies, J. W. Viersma, F. Hagemeijer, Kong I. Lie |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Male
MECHANISM Erythrocytes Hemodynamics Blood Pressure Coronary Disease VASODILATOR Calcium channel blocker Ventricular Function Left Angina Electrocardiography DOUBLE-BLIND Heart Rate STABLE ANGINA PECTORIS Mibefradil CHANNEL-BLOCKING-AGENTS Ejection fraction Middle Aged ISCHEMIA Depression Chemical Anesthesia Female RO-40-5967 Cardiology and Cardiovascular Medicine medicine.drug Adult Tetrahydronaphthalenes medicine.drug_class PROPRANOLOL VERAPAMIL Propranolol PRESSURE CALCIUM CHANNEL BLOCKERS Angina Pectoris Double-Blind Method Heart rate medicine INOTROPIC EFFECTS Humans Radionuclide Ventriculography Aged Pharmacology business.industry medicine.disease EFFICACY Myocardial Contraction CORONARY-ARTERY DISEASE Exercise Test Verapamil Benzimidazoles business |
| Zdroj: | Journal of Cardiovascular Pharmacology, 18(5), 746-751 |
| ISSN: | 0160-2446 |
| Popis: | We screened the antiischemic, hemodynamic, and inotropic effects of different dosages of the new calcium channel blocker Ro 40-5967 in 65 patients with stable effort-induced angina pectoris. In a double-blind way, patients were randomized to receive a single oral dose of 50, 100, or 200 mg Ro 40-5967 or placebo, given as a drinking solution. Left ventricular ejection fraction (LVEF), blood pressure (BP), and heart rate (HR) were measured at rest and during a supine bicycle exercise test on day 0 (baseline) and 2 h after drug intake on day 1. Twenty-four hours later, the bicycle exercise test was repeated. Ro 40-5967 improved exercise duration and resting LVEF. After 200 mg, exercise time increased significantly from 8.4 +/- 0.8 min (mean +/- SEM) to 9.6 +/- 0.7 min (p = 0.018), and LVEF at rest increased from 54.5 +/- 2.2 to 58.1 +/- 2.6% (p = 0.045). Time to 0.1 mV ST-segment depression increased significantly from 4.3 +/- 0.8 to 5.5 +/- 0.9 min in the 100-mg group (p = 0.013) and from 4.3 +/- 1.3 to 5.4 +/- 1.5 min in the 200-mg group (p = 0.027). Maximum ST-segment depression decreased significantly at all dose levels (p = 0.01), with the maximum decrease noted in the 200-mg group (from 0.21 +/- 0.03 to 0.15 +/- 0.02 mV, p = 0.004). BP, HR, and rate-pressure product did not change significantly at rest or at maximum exercise. A single dose of Ro 40-5967 has anti-ischemic properties in patients with stable angina pectoris, with maximum effects obtained after 200 mg. No signs of negative inotropy were noted, and the drug was well tolerated. |
| Databáze: | OpenAIRE |
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