The Relationship Between Dipeptidyl Peptidase-4 Inhibitor Usage and Asymptomatic Amylase Lipase Increment in Type 2 Diabetes Mellitus Patients
| Autor: | Mustafa Araz, Zeynel Abidin Sayiner, Gamze Inan Demiroğlu, Ersin Akarsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
amylase oral antidiabetics Pharmaceutical Science lcsh:RS1-441 Dipeptidyl peptidase-4 inhibitor Saxagliptin Gastroenterology lcsh:Pharmacy and materia medica chemistry.chemical_compound Internal medicine medicine lipase Vildagliptin Amylase biology business.industry medicine.disease chemistry Sitagliptin biology.protein Acute pancreatitis Pancreatitis Hyperamylasemia Molecular Medicine Original Article business dipeptidyl peptidase-4 inhibitors medicine.drug |
| Zdroj: | Turkish Journal of Pharmaceutical Sciences, Vol 17, Iss 1, Pp 68-73 (2020) Turkish Journal of Pharmaceutical Sciences |
| ISSN: | 2148-6247 |
| Popis: | Objectives: In different studies, it has been shown that the use of dipeptidyl peptidase-4 (DPP-4) inhibitors (DPP-4 inh) does not increase the risk of pancreatitis or pancreatic cancer. Although the number of studies involving clinical pancreatitis clinics is sufficient, the number of studies involving clinical non-pancreatitis hyperamylasemia is rare. The aim of the study was to investigate the relationship between DPP-4 inh usage and amylase and lipase increment without clinical pancreatitis symptoms. Materials and Methods: Eighty-seven patients who met the inclusion criteria were enrolled. The patients were divided into 3 groups according to their use of saxagliptin, sitagliptin, or vildagliptin. All patients included in the study were receiving metformin at a dose of 2 g/day. Fasting blood glucose, postprandial blood glucose, HbA1C, serum creatinine, ALT, amylase, and lipase results were recorded at the beginning of treatment and at the end of 3 months. Results: There was an increase in all groups in terms of amylase and lipase values but there was no significant difference between the groups in terms of increase (p>0.05) There was no statistically significant increase in the saxagliptin and vildagliptin groups (p>0.05) when the baseline and 3-month values of lipase and amylase increase were examined. However, there was a statistically significant increase in amylase and lipase in the sitagliptin group (p |
| Databáze: | OpenAIRE |
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