Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo▿
| Autor: | Gustavo Facchini, Fabio T. M. Costa, Stefanie C. P. Lopes, Francisco L. S. Rodrigues, Paulo Nogueira, Uta Goelnitz, Nelson Durán, Giselle Z. Justo, Yara C. Blanco, Gerhard Wunderlich, Marcelo Brocchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Indoles
Plasmodium falciparum Drug Resistance Parasitemia Microbiology Plasmodium chabaudi Apicomplexa Antimalarials Mice Parasitic Sensitivity Tests In vivo parasitic diseases medicine Animals Humans Pharmacology (medical) Malaria Falciparum Pharmacology biology Chromobacterium Chloroquine biology.organism_classification medicine.disease In vitro Malaria Mice Inbred C57BL Infectious Diseases Treatment Outcome Susceptibility Chromobacterium violaceum Bacteria |
| Popis: | Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum . It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi -infected mice from a lethal challenge. |
| Databáze: | OpenAIRE |
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