Racial differences in CD8+ T cell infiltration in breast tumors from Black and White women

Autor: Tongguang Cheng, Thaer Khoury, Gary R. Zirpoli, Leighton Stein, Yara Abdou, Wiam Bshara, Song Yao, Rochelle Payne Ondracek, Kristopher Attwood, Elisa V. Bandera, Angela Omilian, Christine B. Ambrosone
Rok vydání: 2020
Předmět:
Adult
Oncology
medicine.medical_specialty
Receptor
ErbB-2
T cell
Population
Estrogen receptor
Disparities
Breast Neoplasms
CD8-Positive T-Lymphocytes
lcsh:RC254-282
White People
Young Adult
03 medical and health sciences
Breast cancer
Lymphocytes
Tumor-Infiltrating
0302 clinical medicine
Immune system
Surgical oncology
Internal medicine
medicine
Humans
Cytotoxic T cell
education
Aged
030304 developmental biology
0303 health sciences
education.field_of_study
business.industry
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
CD8+
Prognosis
medicine.disease
Immune infiltrates
Black or African American
Survival Rate
medicine.anatomical_structure
Receptors
Estrogen
Case-Control Studies
030220 oncology & carcinogenesis
Women's Health
Female
Receptors
Progesterone
business
CD8
Research Article
Follow-Up Studies
Zdroj: Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-10 (2020)
ISSN: 1465-542X
DOI: 10.1186/s13058-020-01297-4
Popis: Background African American/Black women with breast cancer have poorer survival than White women, and this disparity persists even after adjusting for non-biological factors. Differences in tumor immune biology have been reported between Black and White women, and the tumor immune milieu could potentially drive racial differences in breast cancer etiology and outcome. Methods We examined the association of CD8+ cytotoxic T cells with clinical-pathological variables in the Women’s Circle of Health Study (WCHS) population of predominantly Black breast cancer patients. We evaluated 688 invasive breast tumor samples (550 Black, 138 White) using immunohistochemical staining of tissue microarray slides. CD8+ T cells were scored for each patient tumor sample with digital image analysis. Results Black women had a significantly higher percentage of high-grade, estrogen receptor (ER)-negative, and triple-negative tumors than White women and significantly higher CD8+ T cell density (median 87.6/mm2 vs. 53.1/mm2; p + T cell density was significantly higher in younger patients and patients with high-grade and ER/PR-negative tumors. No significant associations were observed between CD8+ T cell density and overall survival or breast cancer-specific survival in the overall population, or when Black patients were analyzed as a separate group. However, when stratified by subtype, Black women with triple-negative breast cancer and high CD8+ T cell density showed a trend towards better overall survival in comparison with patients with low CD8+ T cell density (HR = 0.51; 95% CI 0.25–1.04). Conclusions Our data raise the possibility that distinct mechanisms of immune cell action may occur in different racial groups.
Databáze: OpenAIRE
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