Incidence of cancer in children born after in-vitro fertilization
| Autor: | Alison Venn, Paul A.L. Lancaster, Andrew L. Speirs, Fiona Bruinsma, David L. Healy |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Victoria medicine.drug_class Population Twins Fertilization in Vitro Reproductive technology Pregnancy Neoplasms Birth Weight Humans Medicine education Fertility drugs Gynecology education.field_of_study business.industry Obstetrics Incidence Incidence (epidemiology) Rehabilitation Infant Newborn Obstetrics and Gynecology Cancer registry Standardized mortality ratio Reproductive Medicine Child Preschool Cohort Female business Follow-Up Studies Cohort study |
| Zdroj: | Human Reproduction. 15:604-607 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/15.3.604 |
| Popis: | Evaluation of the long-term health of children born using in-vitro fertilization (IVF) provides important information to clinicians and consumers. Until very recently, there have been no published data on the incidence of cancer in children conceived as a result of IVF, despite a number of case reports of neuroblastoma in children conceived using fertility drugs. This study used a record-linkage cohort design to investigate the incidence of cancer in children born after IVF. The study included all conceptions using assisted reproductive technologies between 1979 and 1995 at two clinics in Victoria, Australia that resulted in a live birth. Data on births were linked with a population-based cancer registry to determine the number of cases of cancer that occurred. The standardized incidence ratio (SIR) was calculated by comparing the observed number of cases to the expected number of cases. The final cohort included 5249 births. The median length of follow-up was 3 years, 9 months (range 0-15 years). In all, 4.33 cases of cancer were expected and six were observed, giving a SIR of 1.39 (95% CI 0.62-3.09). This study found that children conceived using IVF and related procedures did not have a significantly increased incidence of cancer in comparison to the general population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|