Intrathecal anti‐ CD 20 efficiently depletes meningeal B cells in CNS autoimmunity
| Autor: | Silke Kinzel, Claude C.A. Bernard, Sarah Traffehn, Bernhard Hemmer, Linda Feldmann, Klaus Lehmann-Horn, Christine Stadelmann, Wolfgang Brück, Martin S. Weber, Florentine Radelfahr |
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| Rok vydání: | 2014 |
| Předmět: |
anti-CD20
meningeal B cells CNS autoimmunity Pathology medicine.medical_specialty Central nervous system Intrathecal 03 medical and health sciences 0302 clinical medicine medicine Anti cd20 030304 developmental biology 0303 health sciences biology business.industry General Neuroscience Multiple sclerosis Experimental autoimmune encephalomyelitis Cns autoimmunity medicine.disease 3. Good health medicine.anatomical_structure Immunology biology.protein Systemic administration Neurology (clinical) Antibody Brief Communications business 030217 neurology & neurosurgery |
| Zdroj: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.71 |
| Popis: | Clinical trials revealed that systemic administration of B-cell-depleting anti-CD20 antibodies can hold lesion formation in the early relapsing-remitting phase of multiple sclerosis (MS). Throughout the secondary-progressive (SP) course of MS, pathogenic B cells may, however, progressively replicate within the central nervous system (CNS) itself, which is largely inaccessible to systemic anti-CD20 treatment. Utilizing the murine MS model of experimental autoimmune encephalomyelitis, we show that intrathecal (i.t.) administration of anti-CD20 alone very efficiently depletes meningeal B cells from established CNS lesions. In SP-MS patients, adding i.t. administration of anti-CD20 to its systemic use may be a valuable strategy to target pathogenic B-cell function. peerReviewed |
| Databáze: | OpenAIRE |
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