The Role of Leptin in the Association between Obesity and Psoriasis
| Autor: | Jae Youl Cho, Jaehyeon Hwang, Tae-Kyung Han, Ju Ah Yoo, Jongchan Yoon, Hyungkee Yoon, Jongsung Lee, Seoljun An |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Leptin
0301 basic medicine medicine.medical_specialty Pro-inflammatory cytokines Adipose tissue Adipokine Inflammation Review Biochemistry 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine Psoriasis Drug Discovery medicine Glucose homeostasis Obesity Pharmacology business.industry digestive oral and skin physiology Interleukin medicine.disease 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Molecular Medicine medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 2005-4483 1976-9148 |
| DOI: | 10.4062/biomolther.2020.054 |
| Popis: | Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is abnormally altered in a manner that increases the body's vulnerability to immune diseases, such as psoriasis. Psoriasis is considered a chronic inflammatory skin disease which is closely associated with being overweight and obese. Additionally, secretion of leptin, a type of adipokine, increases dependently on adipose cell size and adipose accumulation. Likewise, high leptin levels also aggravate obesity via development of leptin resistance, suggesting that leptin and obesity are closely related. Leptin induction in psoriatic patients is mainly driven by the interleukin (IL)-23/helper T (Th) 17 axis pathway. Furthermore, leptin can have an effect on various types of immune cells such as T cells and dendritic cells. Here, we discuss the relationship between obesity and leptin expression as well as the linkage between effect of leptin on immune cells and psoriasis progression. |
| Databáze: | OpenAIRE |
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