Advances in the strategies for designing receptor-targeted molecular imaging probes for cancer research
| Autor: | Kwangmeyung Kim, Ick Chan Kwon, Young Ji Ko, Woo Jun Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Tumor targeting
Pharmaceutical Science Receptors Cell Surface 02 engineering and technology Computational biology Imaging modalities 03 medical and health sciences Neoplasms medicine Animals Humans Tumor location Receptor 030304 developmental biology 0303 health sciences Luminescent Agents Modality (human–computer interaction) business.industry Optical Imaging Cancer Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology medicine.disease Magnetic Resonance Imaging Tumor tissue Molecular Imaging Positron-Emission Tomography Molecular imaging 0210 nano-technology business |
| Zdroj: | Journal of Controlled Release. 305:1-17 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2019.04.030 |
| Popis: | Receptor targeted imaging has emerged as a promising tools for imaging tumor tissues. Receptor targeted molecular imaging confers critical information on clinicians including tumor location, expression level of certain receptors, and biological process, which enables early diagnosis and treatment of tumor to control cancer mortality. Receptor targeted probe design is a key to successfully deliver accurate information through many imaging modalities. When designing receptor targeted imaging probes, a variety of targeting receptors and imaging modalities are selected depending on type of cancer because overexpression of receptors are variant among tumors and each imaging modality has advantages and disadvantages. Subsequently selecting appropriate tumor targeting strategies is critical to efficiently visualize tumor of interest. In this review, we presented the strategies commonly used for designing receptor targeted probes and summarized the recent studies that implemented each strategies. |
| Databáze: | OpenAIRE |
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