Plasma antioxidant enzymes and clastogenic factors as possible biomarkers of colorectal cancer risk
| Autor: | Silvana Hrelia, Carolina Poli, Patrizia Hrelia, Antonio Colecchia, Francesca Maffei, Juan Manuel Zolezzi Moraga, Francesca Pasqui, Davide Festi, Marco Malaguti, Cristina Angeloni |
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| Přispěvatelé: | F. Maffei, C. Angeloni, M. Malaguti, J. M. Z. Moraga, F. Pasqui, C. Poli, A. Colecchia, D. Festi, P. Hrelia, S. Hrelia. |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty GENETIC DAMAGE Colorectal cancer Health Toxicology and Mutagenesis Glutathione reductase BIOMARKERS medicine.disease_cause Gastroenterology Superoxide dismutase Biomarkers Genetic damage Oxidative stress Risk Factors Internal medicine Genetics medicine Biomarkers Tumor Humans Molecular Biology Aged Glutathione Transferase COLORECTAL CANCER Cancer prevention Micronucleus Tests biology business.industry Superoxide Dismutase Cancer Middle Aged medicine.disease Catalase Oxidative Stress Glutathione Reductase Occult Blood Immunology Micronucleus test biology.protein Population study Female business Colorectal Neoplasms Mutagens |
| Zdroj: | Mutation research. 714(1-2) |
| ISSN: | 0027-5107 |
| Popis: | Oxidative damage plays an important role in the pathogenesis of colorectal (CR) cancer. This study investigated the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione-S-transferase (GST) in plasma of 82 participants of a screening program for CR cancer prevention (30 females and 52 males; age 50-70 years). All subjects resulted positive to fecal occult blood test and were subsequently classified, according to the colonoscopy and histological findings, in patients with CR cancer, patients with colorectal polyps or controls. Furthermore, the activity of clastogenic factors (CFs) in plasma from study population was measured as the ability of inducing micronuclei (MN) in vitro in peripheral of a healthy donor. CAT and GR activities were significantly lower in CR cancer patients compared to controls (P< 0.05) and polyps groups (P< 0.05). SOD activity was significantly higher in patients with CR cancer than in polyp (P |
| Databáze: | OpenAIRE |
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