Combination of carotenoids from Spirulina and PLA/PLGA or PHB: New options to obtain bioactive nanoparticles
| Autor: | Alessandro de Oliveira Rios, Janice Izabel Druzian, Vanessa Stahl Hermes Poletto, Ingrid Graça Ramos, Camila Duarte Ferreira Ribeiro, Priscilla Quenia Muniz Bezerra, Bruna Aparecida Souza Machado, Jorge Alberto Vieira Costa, Itaciara Larroza Nunes, Larissa Santos Assunção |
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| Rok vydání: | 2020 |
| Předmět: |
Polyesters
Dispersity Nanoparticle Hydroxybutyrates 01 natural sciences Analytical Chemistry Excipients chemistry.chemical_compound 0404 agricultural biotechnology Polylactic Acid-Polyglycolic Acid Copolymer Zeta potential Spirulina Particle Size Carotenoid chemistry.chemical_classification Drug Carriers 010401 analytical chemistry 04 agricultural and veterinary sciences General Medicine Polymer Apparent viscosity beta Carotene 040401 food science Carotenoids 0104 chemical sciences PLGA chemistry Chemical engineering Nanoparticles Particle size Food Science |
| Zdroj: | Food chemistry. 346 |
| ISSN: | 1873-7072 |
| Popis: | The use of poly-β-hydroxybutyrate (PHB) is an alternative polymer that can be considered environment friendly and renewable to prepare nanoparticles of carotenoids. This study aimed to develop and characterize aqueous dispersion nanoparticles and lyophilized nanoparticles of carotenoid extract obtained from Spirulina sp. LEB 18 by nanoprecipitation, using poly d,l-lactic acid (PLA)/poly d,l-lactic-co-glycolic acid (PLGA) (75:25 w/w) or PHB as encapsulants. The samples were characterized for the particle size, polydispersity index, zeta potential, apparent viscosity, pH, color parameters, ultraviolet-visible (UV/Vis) spectrophotometry, carotenoid profile, encapsulation efficiency, morphology, and thermal analysis. Nanoparticles containing microalgae carotenoid extract showed average particle diameter on a nanoscale ( 80%) when compared to nanoparticles containing β-carotene synthetic. PHB or PLA/PLGA as encapsulating material in the production of nanoparticles from microalgae carotenoids can be a polymeric alternative capable of promoting greater stability and application of carotenoids. |
| Databáze: | OpenAIRE |
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