N-terminal pro-brain natriuretic peptide and angiotensin-converting enzyme-2 levels and their association with postoperative cardiac complications after emergency orthopedic surgery
| Autor: | Julie E. Ryan, Louise M Burrell, Carol P Chong, Elena Velkoska, Wen Kwang Lim, William J. van Gaal, Judy Savige |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Heart Diseases medicine.drug_class Population Peptidyl-Dipeptidase A Postoperative Complications Predictive Value of Tests Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Orthopedic Procedures Myocardial infarction Postoperative Period Protein Precursors education Aged Retrospective Studies Aged 80 and over education.field_of_study biology business.industry Atrial fibrillation Odds ratio Perioperative Middle Aged medicine.disease Prognosis Troponin Confidence interval Peptide Fragments biology.protein Cardiology Female Angiotensin-Converting Enzyme 2 Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | The American journal of cardiology. 109(9) |
| ISSN: | 1879-1913 |
| Popis: | The prognostic usefulness of the cardiac biomarkers N-terminal pro-brain natriuretic peptide (NT-proBNP) and angiotensin-converting enzyme 2 (ACE-2), in predicting adverse cardiac outcomes after orthopedic surgery is not well studied. The aim of our study was to determine the usefulness of perioperative NT-proBNP and ACE-2 for predicting cardiac events after emergency orthopedic surgery. The perioperative NT-proBNP and ACE-2 levels were determined in 187 consecutive patients aged >60 years who underwent orthopedic surgery with 1 year of follow-up for any cardiac complications (defined as acute myocardial infarction, congestive cardiac failure, atrial fibrillation, or major arrhythmia) and death. Of the 187 patients, 20 (10.7%) sustained an in-hospital postoperative cardiac complication. The total all-cause in-hospital and 1-year mortality rate was 1.6% (3 of 187) and 8.6% (16 of 187), respectively. The median preoperative and postoperative NT-proBNP level was greater in patients who sustained an in-hospital cardiac event than in those who had not (386 vs 2,273 pg/ml, p |
| Databáze: | OpenAIRE |
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