Receptors for steroid hormones: membrane-associated and nuclear forms
| Autor: | I. Nemere, M. R. Walters |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Receptors Steroid Estrogen receptor Receptors Cytoplasmic and Nuclear Immune receptor Peptide hormone Cellular and Molecular Neuroscience Internal medicine medicine Animals Humans Vitamin D Receptor Molecular Biology PELP-1 Pharmacology Chemistry Cell Membrane Estrogens Cell Biology Sex hormone receptor Cell biology Endocrinology Nuclear receptor Gene Expression Regulation Molecular Medicine Hormone |
| Zdroj: | Cellular and molecular life sciences : CMLS. 61(18) |
| ISSN: | 1420-682X |
| Popis: | Steroid hormones are now recognized to act through both nuclear and membrane-associated receptors. In this review we focus on receptors for estrogen and the vitamin D metabolite 1,25-dihydroxyvitamin D(3). While the nuclear receptors are part of a 'superfamily' with common structural elements, membrane receptors are more diverse, ranging from variants of the nuclear forms to unrelated proteins. We conclude that both rapid (membrane-initiated) actions, as well as regulation of gene transcription, are necessary to explain the complex actions of steroid hormones on target cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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