Human mismatch repair genes and their association with hereditary non-polyposis colon cancer
| Autor: | R J Bollag, Michael F. Kane, Richard Fishel, L.G. Smith, D. T. Bishop, P Chapman, P. J. Finan, Lori J. Wirth, Graham Warren, R. M. Liskay, Lipford J, A R Godwin, Magnus Nordenskjöld, C.E. Bronner, Sean M. Baker, Mary Kay Lescoe, Annika Lindblom, M.R.S. Rao, N. R. Hall, Jack D. Griffith, Nancy A. Jenkins, Neal G. Copeland, Judy Garber, Pia Tannergård, A. Ewel, D.C. Ward, Earabino C, S. Lee, E. Merchant, Richard D. Kolodner, Paul T. Morrison, John Burn |
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| Rok vydání: | 1994 |
| Předmět: |
Genetics
Male DNA Repair Colorectal cancer Chromosome Chromosome Mapping DNA Neoplasm Biology medicine.disease Biochemistry Biological Evolution Colorectal Neoplasms Hereditary Nonpolyposis Pedigree DNA-Binding Proteins Fungal Proteins MutS Homolog 2 Protein Mutation medicine Humans DNA mismatch repair Female Cloning Molecular Molecular Biology Gene |
| Zdroj: | Cold Spring Harbor symposia on quantitative biology. 59 |
| ISSN: | 0091-7451 |
| Popis: | Hereditary non-polyposis colon cancer (HNPCC) may affect up to 1 in 200 people in industrialized nations (Bishop and Thomas 1990; Lynch et al. 1991, 1993; Peltomaki et al. 1993b). Four genes have been identified in which inherited mutations appear to cause HNPCC. hMSH2 on chromosome 2p21-22 appears to account for up to 60% of HNPCC (Fishel et al. 1993; Leach et al. 1993; Sandkuijl and Bishop 1993; Nystrom-Lahti et al. 1994), hMLH1 on chromosome 3p21 appears to account for up to 30% of HNPCC (Bronner et al. 1994; Nystrom-Lahti et al. 1994; Papadopoulos et al. 1994), and hPMS1 on chromosome 2q31-33 and hPMS2 on chromosome 7p21 may account for 5% of HNPCC (Nicolaides et al. 1994). |
| Databáze: | OpenAIRE |
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