Prospective evaluation on the effect of interobserver variability of digital rectal examination on the performance of the Rotterdam Prostate Cancer Risk Calculator

Autor: Eduardo Carrasquinho, Daan Nieboer, Isaac Braga, Luís Osório, Nuno Pereira-Azevedo, Eduardo Cardoso de Oliveira, V. Cavadas, Avelino Fraga, Monique J. Roobol, Jan F.M. Verbeek
Přispěvatelé: Universidade do Minho, Urology
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Prostate biopsy
Biopsy
Medicina Básica [Ciências Médicas]
030232 urology & nephrology
urologic and male genital diseases
Prostate cancer
0302 clinical medicine
Prospective Studies
Prospective cohort study
Early Detection of Cancer
Digital Rectal Examination
Ultrasonography
Observer Variation
medicine.diagnostic_test
Prostate
Middle Aged
prostate cancer
female genital diseases and pregnancy complications
030220 oncology & carcinogenesis
Area Under Curve
Cohort
Ciências Médicas::Medicina Básica
risk calculator
Radiology
medicine.symptom
medicine.medical_specialty
Urology
Asymptomatic
Risk Assessment
03 medical and health sciences
SDG 3 - Good Health and Well-being
Predictive Value of Tests
medicine
Humans
decision curve analysis
Aged
Science & Technology
Receiver operating characteristic
Portugal
business.industry
Prostatic Neoplasms
Rectal examination
Prostate-Specific Antigen
medicine.disease
Surgery
ROC Curve
business
Zdroj: International Journal of Urology, 24(12), 826-832. Wiley-Blackwell Publishing Ltd
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 0919-8172
Popis: Objectives To assess the level of agreement between digital rectal examination findings of two urologists and its effect on risk prediction using the digital rectal examination-based Rotterdam Prostate Cancer Risk Calculator. Methods The study sample consisted of a prospective cohort of asymptomatic unscreened men with prostate-specific antigen ≤50.0 ng/mL and transrectal ultrasound volume ≤110 mL who underwent transrectal ultrasound-guided prostate biopsy. Both urologists’ digital rectal examination findings were graded normal or abnormal (nodularity and/or induration), and volume classified as 25, 40 or 60 mL, according to the risk calculator algorithm. Interrater agreement analysis using Cohen's kappa (κ) statistic was carried out to determine consistency of digital rectal examination outcome and volume assessment. Receiver operating characteristic curve analysis and calibration plots were constructed to determine the effect of interrater differences. Decision curve analysis was applied to evaluate the clinical usefulness of the model. Results Of the 241 men included in the study, 41% (n = 98) had prostate cancer (81 were clinically significant, i.e. Gleason ≥3 + 4). There was substantial agreement in the digital rectal examination (abnormal/normal; κ = 0.78; P
Databáze: OpenAIRE
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