Inhibition of antigen presentation by Brucella: many more than many ways
| Autor: | Paula Barrionuevo, Guillermo H. Giambartolomei |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine CIENCIAS MÉDICAS Y DE LA SALUD 030106 microbiology Immunology Antigen presentation Inmunología Brucella Microbiology Brucellosis 03 medical and health sciences Immune system TLR MHC class I ANTIGEN PRESENTATION Animals Humans BRUCELLA MACROPHAGES Pathogen Immune Evasion Antigen Presentation biology Macrophages Toll-Like Receptors Histocompatibility Antigens Class II Evasion (ethics) biology.organism_classification Immune surveillance Medicina Básica 030104 developmental biology Infectious Diseases biology.protein CD8 Signal Transduction |
| Zdroj: | Microbes and Infection. 21:136-142 |
| ISSN: | 1286-4579 |
| DOI: | 10.1016/j.micinf.2018.12.004 |
| Popis: | Brucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival. Fil: Barrionuevo, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Giambartolomei, Guillermo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina |
| Databáze: | OpenAIRE |
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