Safety assessment of EPA+DHA canola oil by fatty acid profile comparison to various edible oils and fat-containing foods and a 28-day repeated dose toxicity study in rats
| Autor: | Bennard van Ravenzwaay, Brandy Riffle, Carl Andre, R. Buesen, Heike Marxfeld, Jordan B. Sottosanto, Volker Strauss, Christine Wandelt, Elizabeth A. Lipscomb |
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| Rok vydání: | 2018 |
| Předmět: |
Male
food.ingredient Food Safety Docosahexaenoic Acids Urinalysis Toxicology Risk Assessment food Fish Oils Mortierella Animals Food science Rats Wistar Canola Menhaden Oil chemistry.chemical_classification Goats Body Weight Decapodiformes Fishes Fatty acid General Medicine Fish oil Eicosapentaenoic acid chemistry Eicosapentaenoic Acid Docosahexaenoic acid Toxicity lipids (amino acids peptides and proteins) Cattle Female Rapeseed Oil Chickens Blood Chemical Analysis Food Science Polyunsaturated fatty acid |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 124 |
| ISSN: | 1873-6351 |
| Popis: | The omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are recognized for their health-promoting qualities. Marine fish and fish oil currently provide the main sources of EPA and DHA for human consumption. An alternative plant-based source of EPA and DHA is provided by EPA + DHA canola event LBFLFK (LBFLFK). A comparative analysis and a 28-day toxicity study assessed the safety of LBFLFK refined, bleached, and deodorized (RBD) oil. Thirty-one different commercially-obtained fat and oil samples were tested, and principal component analysis showed that the overall fatty acid profile of LBFLFK RBD oil was most similar to Mortierella alpina oil and salmon flesh. Samples with the fewest differences in the presence or absence of individual fatty acids compared to LBFLFK RBD oil were menhaden oil and some other fish oils. In a 28-day toxicity study, LBFLFK RBD oil was administered by oral gavage to male and female Wistar rats. No signs of toxicity were evident and no adverse effects were noted in clinical observations, clinical pathology, or histopathology. Overall, these studies support the safety of LBFLFK RBD oil as a source of EPA and DHA for human consumption. |
| Databáze: | OpenAIRE |
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