Addition of clonidine and fentanyl to epidural blockade with 0.5% bupivacaine
| Autor: | Edward A. Shipton, Hermanus S. Schoeman, Julian C. S. Murphy, Ivan Havlik |
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| Rok vydání: | 1995 |
| Předmět: |
Bupivacaine
Agonist medicine.medical_specialty business.industry medicine.drug_class medicine.medical_treatment Drug Synergism General Medicine Clonidine Fentanyl Analgesia Epidural Anesthesiology and Pain Medicine Anesthesia Anesthesiology medicine Humans General anaesthesia business Diazepam Saline medicine.drug |
| Zdroj: | Canadian journal of anaesthesia = Journal canadien d'anesthesie. 42(6) |
| ISSN: | 0832-610X |
| Popis: | To the Editor: Clonidine, an alpha2 agonist produces variable analgesia when given epidurally 1.2 but without respiratory depression. 2,3 Synergy between epidural opioids and clonidine in producing analgesia has also been reported. 2 In a double-blinded, randomised study, 26 patients undergoing major gynaecological surgery received lumbar epidural block with 17 ml 0.5% plain bupivacaine. In addition, to evaluate the extent of the synergy, they received epidurally: Group I Group 2 saline 0.9% 2 ml clonidine 150 Isg made up to 2 ml with 0.9% saline Group 3 fentanyl 100 Ixg (2 ml) or Group 4 clonidine 75 ~tg plus fentanyl 50 ~tg made up to 2 ml with 0.9% saline No patient had received any analgesia for at least 24 hr before surgery. All were premeditated with diazepam 10 m g p o two hours before surgery. In no group was analgesia sufficient for surgery produced. Most patients required general anaesthesia. The duration of analgesia (min) from completion of the epidural block until patients required further analgesia in the four groups is shown in the Table. |
| Databáze: | OpenAIRE |
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