Changes of serum osteocalcin, calcium, and potassium in a rat model of type 2 diabetes
| Autor: | Chen Xu, Chang Yuan Xiong, Ying Xiong, Lin Xiao, Jun Ding, Tao Yang, Xian Mo Wang, Zhong Gui Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Osteocalcin Biophysics chemistry.chemical_element Type 2 diabetes Calcium Biochemistry Group A Group B Bone and Bones Rats Sprague-Dawley Diabetes mellitus Internal medicine medicine Animals biology Phosphorus Cell Biology General Medicine medicine.disease Alkaline Phosphatase Rats Disease Models Animal Endocrinology chemistry Diabetes Mellitus Type 2 biology.protein Potassium Alkaline phosphatase |
| Zdroj: | Cell biochemistry and biophysics. 71(1) |
| ISSN: | 1559-0283 |
| Popis: | Changes in serum levels of calcium (Ca), phosphorus (P), Ca phosphate, alkaline phosphatase (AKP), and osteocalcin (BGP) were assessed in a model of type 2 diabetes in 8-weeks-old Sprague–Dawley rats. Throughout the study, the animals in Group A consumed high-carbohydrate, high-fat diet and were administered two intraperitoneal injections of streptozocin (STZ) at 4 (25 mg/kg) and 8 (40 mg/kg) weeks after diet initiation. Animals in Group B received similar diet but intraperitoneal injections with citrate buffer. The control group rats (Group C) were fed normal diet and received citrate buffer injections. The Ca levels in Group A were significantly decreased at 12 and 16 weeks, while P levels were significantly lower at 8, 12, and 16 weeks after the first STZ injection (p |
| Databáze: | OpenAIRE |
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