Relation between Body Fat and Liver Fat Accumulation and Cytokine Pattern in Non-Alcoholic Patients with Chronic HCV Infection
| Autor: | R. Alemán-Valls, J. López-Prieto, H. Alvarez-Argüelles, Pedro Abreu-Gonzalez, Francisco Santolaria-Fernández, A. Castellano-Higuera, Emilio González-Reimers, F. Valladares-Parrilla, M.J. de la Vega-Prieto |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Hepatitis C virus Medicine (miscellaneous) Intra-Abdominal Fat medicine.disease_cause Severity of Illness Index Virus Body Mass Index Adipokines medicine Humans Hepatitis Tissue Inhibitor of Metalloproteinase-1 Nutrition and Dietetics business.industry Fatty liver virus diseases Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Obesity Fatty Liver Oxidative Stress Adipose Tissue Obesity Abdominal Immunology Cytokines Female Waist Circumference Steatohepatitis business Body mass index |
| Zdroj: | Annals of Nutrition and Metabolism. 55:351-357 |
| ISSN: | 1421-9697 0250-6807 |
| DOI: | 10.1159/000252351 |
| Popis: | Background: Liver steatosis in chronic hepatitis C virus (HCV) infection is multifactorial. Therefore, there is not necessarily a relation between obesity and liver fat.On the other hand, body fat secretes cytokines, and cytokines and oxidative damage play important roles on progression of liver disease. Methods: We analyzed the relationships between liver fat (assessed by histomorphometry) and trunk and subcutaneous fat (waist perimeter, triceps skinfold, BMI); the relationships between liver and body fat and cytokines (IL-6, TNF-α, IL-8, IFN-γ, IL-4), adipokines (adiponectin and TIMP-1), and serum malondiladehyde and antioxidants (glutathione peroxidase and superoxide dismutase (SOD) activities); and the relationships of these data with histological changes in 40 HCV-infected non-alcoholic patients. Results: Significant correlations were found between liver fat and waist perimeter and BMI, and between serum TIMP-1 and liver fat. Serum TIMP-1 was significantly related to body fat stores; serum IL-6 and IFN-γ were related to histological inflammation. Patients with waist perimeter >102 cm (men) or 88 cm (women) showed increased liver fat. In 38.8% of non-obese patients, liver fat accumulation was intense. Conclusions: There is a relationship between visceral fat, serum TIMP-1 and liver steatosis. However, at least in some patients, factors different from mere adiposity play a role in liver steatosis. |
| Databáze: | OpenAIRE |
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