The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population
| Autor: | Ha Youn Lee, Deog Kyeom Kim, Eun Young Heo, Ye Jin Lee, Hee Soon Chung, Jung Kyu Lee, Tae Yun Park, Hye Rin Kang, Seung Ho Choi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Spirometry
Adult Male medicine.medical_specialty Vital capacity Population Vital Capacity Respiratory Diseases Gastroenterology Severity of Illness Index 03 medical and health sciences FEV1/FVC ratio Pulmonary Disease Chronic Obstructive 0302 clinical medicine Internal medicine Forced Expiratory Volume medicine Humans 030212 general & internal medicine Community Health Services Endoscopy Digestive System Reflux esophagitis education Esophagitis Peptic Lung Retrospective Studies COPD education.field_of_study medicine.diagnostic_test Esophagogastroduodenoscopy business.industry Incidence (epidemiology) General Medicine Middle Aged medicine.disease Respiratory Function Tests Case-Control Studies Gastroesophageal Reflux Original Article Female business |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Background The impact of reflux esophagitis on the decline of lung function has been rarely reported. This study was performed to evaluate the association between erosive reflux esophagitis and lung function changes. Methods We included patients with normal lung function who underwent esophagogastroduodenoscopy for health screening from a health screening center. Patients with persistent erosive reflux esophagitis on two discrete endoscopic examinations were designated as the erosive reflux esophagitis group. We also selected patients without erosive reflux esophagitis and matched them 1:4 with patients from the erosive reflux esophagitis group. We estimated annual forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) changes from baseline and compared these estimates by the linear mixed regression model. We also estimated the biannual incidence of chronic obstructive pulmonary disease (COPD). Results In total, 1,050 patients (210 patients with erosive reflux esophagitis, and 840 matched controls) were included. The median follow-up duration for spirometry was six years. In patients with erosive reflux esophagitis, mild reflux esophagitis (A grade) was most common (165 patients, 78.6%). The adjusted annual FEV1 change in patients with erosive reflux esophagitis was −51.8 mL/yr, while it decreased by 46.8 mL/yr in controls (P = 0.270). The adjusted annual FVC decline was similar between the two groups (−55.8 vs. −50.5 mL/yr, P = 0.215). The estimated COPD incidence during the follow-up period was not different between the erosive reflux esophagitis and control groups. Conclusion In patients with normal lung function, the presence of erosive reflux esophagitis did not affect the annual declines in FEV1 or FVC. Graphical Abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|