Phyllodes tumour of the breast: clinical follow-up of 33 cases of this rare disease
| Autor: | Miriam Lenhard, Ingo Bauerfeind, Steffen Kahlert, Isabelle Himsl, Nina Ditsch, Michael Untch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Breast Neoplasms Rare Diseases Phyllodes Tumor Breast-conserving surgery Humans Medicine Lymph node Aged Retrospective Studies business.industry Axillary Lymph Node Dissection Obstetrics and Gynecology Phyllodes tumor Retrospective cohort study Middle Aged medicine.disease Surgery medicine.anatomical_structure Reproductive Medicine Lymphatic Metastasis Female Breast disease Neoplasm Recurrence Local business Mastectomy Follow-Up Studies Rare disease |
| Popis: | Objective The “cystosarcoma phyllodes” of the breast is a rare entity which accounts for 0.5% of all breast neoplasms. The aim of our study was to analyse the clinical management with respect to patient outcome. Study design The data of 5270 patients with primary breast neoplasms treated in our department between 1984 and 2005 were retrospectively analysed for the histopathologic diagnosis of a cystosarcoma phyllodes. The clinical data was analysed with respect to tumour grading and size, treatment and prognosis. Results Retrospective analysis of 5270 patients with primary breast neoplasms revealed 33 patients. In the histopathological analysis, tumour grade was classified as benign in 40%, borderline in 27% and malignant in 33% of patients. Breast conserving surgery was conducted in 58% of the patients, mastectomy in 42%. Only one patient was treated with adjuvant radiotherapy after primary surgery. Mean tumour size was 6.9 cm, and no lymph node infiltration was found in the 10 patients who received axillary lymph node dissection. Local recurrence occurred in eight patients (26%). The local recurrence rate was 50% in malignant, 20% in borderline and only 8% in benign tumours. Distant metastases were seen in three patients (9%) with malignant phyllodes tumours. Neither regarding age at primary diagnosis nor in tumour size there was a significant difference between patients with local recurrence or metastatic spread and those without (p = 0.284 tumour size; p = 0.739 for age; Mann–Whitney U-test). Conclusion Histopathological classification appears to be the strongest prognostic factor in this disease. |
| Databáze: | OpenAIRE |
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