Tissue Engineering of the Urethra: A Systematic Review and Meta-analysis of Preclinical and Clinical Studies

Autor: Wout F.J. Feitz, Joanna IntHout, Toin H. van Kuppevelt, Luuk R.M. Versteegden, Rob B. M. de Vries, Paul K J D de Jonge, Egbert Oosterwijk, Willeke F. Daamen
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Cell Transplantation
Urology
030232 urology & nephrology
Context (language use)
Regenerative Medicine
03 medical and health sciences
0302 clinical medicine
Urethra
Tissue engineering
Internal medicine
Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]
Urethral Diseases
medicine
Animals
Humans
Regeneration
Decellularization
Tissue Engineering
business.industry
Clinical study design
Recovery of Function
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Surgery
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
Urethra repair
Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Meta-analysis
Models
Animal
Female
business
Evidence synthesis
Zdroj: European Urology, 72, 594-606
European Urology, 72, 4, pp. 594-606
ISSN: 0302-2838
Popis: Contains fulltext : 176946.pdf (Publisher’s version ) (Closed access) CONTEXT: Urethra repair by tissue engineering has been extensively studied in laboratory animals and patients, but is not routinely used in clinical practice. OBJECTIVE: To systematically investigate preclinical and clinical evidence of the efficacy of tissue engineering for urethra repair in order to stimulate translation of preclinical studies to the clinic. EVIDENCE ACQUISITION: A systematic search strategy was applied in PubMed and EMBASE. Studies were independently screened for relevance by two reviewers, resulting in 80 preclinical and 23 clinical studies of which 63 and 13 were selected for meta-analysis to assess side effects, functionality, and study completion. Analyses for preclinical and clinical studies were performed separately. Full circumferential and inlay procedures were assessed independently. Evaluated parameters included seeding of cells and type of biomaterial. EVIDENCE SYNTHESIS: Meta-analysis revealed that cell seeding significantly reduced the probability of encountering side effects in preclinical studies. Remarkably though, cells were only sparsely used in the clinic (4/23 studies) and showed no significant reduction of side effects. ln 21 out of 23 clinical studies, decellularized templates were used, while in preclinical studies other biomaterials showed promising outcomes as well. No direct comparison to current clinical practice could be made due to the limited number of randomized controlled studies. CONCLUSIONS: Due to a lack of controlled (pre)clinical studies, the efficacy of tissue engineering for urethra repair could not be determined. Meta-analysis outcome measures were similar to current treatment options described in literature. Surprisingly, it appeared that favorable preclinical results, that is inclusion of cells, were not translated to the clinic. Improved (pre)clinical study designs may enhance clinical translation. PATIENT SUMMARY: We reviewed all available literature on urethral tissue engineering to assess the efficacy in preclinical and clinical studies. We show that improvements to (pre)clinical study design is required to improve clinical translation of tissue engineering technologies.
Databáze: OpenAIRE
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