Plasma-Activated Polyvinyl Alcohol Foils for Cell Growth
| Autor: | Václav Švorčík, Nikola Slepičková Kasálková, Anna Macková, Martina Trávníčková, Petr Slepička, Barbora Ivanovská, Lucie Bacakova, Petr Malinský |
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| Rok vydání: | 2020 |
| Předmět: |
cytocompatibility
Materials science Absorption of water Biocompatibility polymer macromolecular substances Polyvinyl alcohol chemistry.chemical_compound PEG ratio Materials Chemistry chemistry.chemical_classification integumentary system nanoparticle doping technology industry and agriculture Surfaces and Interfaces Polymer Surfaces Coatings and Films plasma treatment chemistry Chemical engineering lcsh:TA1-2040 Colloidal gold tissue engineering PVA Self-healing hydrogels lcsh:Engineering (General). Civil engineering (General) Ethylene glycol surface characterization |
| Zdroj: | Coatings, Vol 10, Iss 1083, p 1083 (2020) Coatings Volume 10 Issue 11 |
| ISSN: | 2079-6412 |
| Popis: | Hydrogels, and not only natural polysaccharide hydrogels, are substances capable of absorbing large amounts of water and physiological fluids. In this study, we set out to optimize the process for preparing polyvinyl alcohol (PVA) hydrogels. Subsequently, we doped PVA foils with cellulose powder, with poly(ethylene glycol) (PEG) or with gold nanoparticles in PEG colloid solutions (Au). The foils were then modified in a plasma discharge to improve their biocompatibility. The properties of PVA foils were studied by various analytical methods. The use of a suitable dopant can significantly affect the surface wettability, the roughness, the morphology and the mechanical properties of the material. Plasma treatment of PVA leads to ultraviolet light-induced crosslinking and decreasing water absorption. At the same time, this treatment significantly improves the cytocompatibility of the polymer, which is manifested by enhanced growth of human adipose-derived stem cells. This positive effect on the cell behavior was most pronounced on PVA foils doped with PEG or with Au. This modification of PVA therefore seems to be most suitable for the use of this polymer as a cell carrier for tissue engineering, wound healing and other regenerative applications. |
| Databáze: | OpenAIRE |
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