Pain and Disability in Low Back Pain can be Reduced Despite No Significant Improvements in Mechanistic Pain Biomarkers
| Autor: | Thomas Graven-Nielsen, Enrico De Martino, Steffan Wittrup Christensen, Thorvaldur Skuli Palsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment B100 rehabilitation Disability Evaluation 03 medical and health sciences 0302 clinical medicine temporal summation 030202 anesthesiology Surveys and Questionnaires pressure pain threshold medicine Noxious stimulus Numeric Rating Scale Humans conditioned pain modulation Prospective Studies Prospective cohort study Balance (ability) Rehabilitation business.industry pain questionnaires C600 Low back pain B900 body regions Anesthesiology and Pain Medicine Nociception Case-Control Studies Physical therapy Female Observational study Neurology (clinical) medicine.symptom business Low Back Pain Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Palsson, T S, Christensen, S W M, De Martino, E & Graven-Nielsen, T 2021, ' Pain and Disability in Low Back Pain can be Reduced Despite No Significant Improvements in Mechanistic Pain Biomarkers ', The Clinical Journal of Pain, vol. 37, no. 5, pp. 330-338 . https://doi.org/10.1097/ajp.0000000000000927 |
| ISSN: | 0749-8047 |
| Popis: | Objective: \ud Altered balance in nociception in response to noxious stimuli is commonly reported in chronic low back pain (LBP). However, it is unclear whether an improvement in the clinical presentation is contingent on a reduction in pain sensitivity. This study investigated whether the quantitative sensory testing (QST) profile changes in people undergoing rehabilitation for LBP. \ud Design: \ud A prospective, observational case-control study. Methods: Forty males and females, 18-40 years' old, (20 with LBP) participated in two sessions. QST was performed at baseline and after discharge from rehabilitation (LBP) or after 3-8 weeks (controls). The QST battery consisted of determining pressure-pain thresholds (PPT) at the low back and shoulder, temporal summation of pain and conditioned pain modulation. Questionnaire data was used to determine pain (Numeric Rating Scale; NRS), disability (Roland-Morris Questionnaire, RMQ), Fear Avoidance Beliefs (FABQ) and The Örebro Musculoskeletal Pain Screening Questionnaire (ÖMPSQ) at baseline and discharge. The treatment effect was determined by calculating the Cohen's d. \ud Results: \ud No significant group x time interactions or main factor effect was found for any of the QST measures. The LBP group reported a significant reduction in NRS (P |
| Databáze: | OpenAIRE |
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