Peptide YY3-36 Decreases Reinstatement of High-Fat Food Seeking during Dieting in a Rat Relapse Model
| Autor: | Sam A. Golden, Jennifer M. Bossert, Yavin Shaham, Sarah M. Gray, Sunila G. Nair, Jamie L. Uejima, Udi E. Ghitza |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Article Heroin Internal medicine Pellet Secondary Prevention medicine Animals Peptide YY Rats Long-Evans Obesity Arc (protein) General Neuroscience digestive oral and skin physiology Antagonist Feeding Behavior Extinction (psychology) Dietary Fats Peptide Fragments Rats Yohimbine Disease Models Animal Endocrinology medicine.symptom Psychology medicine.drug Dieting |
| Zdroj: | The Journal of Neuroscience. 27:11522-11532 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | A major problem in treating obesity is high rates of relapse to maladaptive food-taking habits during dieting. This relapse is often provoked by acute re-exposure to palatable food, food-associated cues, or stress. We used a reinstatement model, commonly used to study relapse to abused drugs, to explore the effect of peptide YY3-36 (PYY3-36) on reinstatement of high-fat (35%, 45 mg pellets) food seeking induced by acute exposure to the pellets (pellet priming), a cue previously associated with pellet delivery (pellet cue), or yohimbine (2 mg/kg, a pharmacological stressor). Rats were placed on a restricted diet (16 g of chow per day) and lever-pressed for the pellets for 9–12 sessions (6 h/d, every 48 h); pellet delivery was paired with a tone–light cue. They were then given 10–20 extinction sessions wherein lever presses were not reinforced with the pellets and subsequently tested for reinstatement of food seeking. Systemic PYY3-36 injections (100–200 μg/kg) decreased pellet priming- and pellet cue-induced reinstatement of food seeking but not yohimbine-induced reinstatement. Arcuate nucleus (Arc) injections of PYY3-36 (0.4 μg per side) decreased pellet priming-induced reinstatement. The attenuation of pellet priming-induced reinstatement by systemic PYY3-36 was reversed by systemic (2 mg/kg) but not Arc (0.5 μg per side) injections of the Y2 receptor antagonist BIIE0246. Arc PYY3-36 injections did not decrease pellet cue-induced reinstatement. Finally, systemic PYY3-36 injections had minimal effects on ongoing food self-administration or heroin priming- or heroin cue-induced reinstatement of heroin seeking. These data identify an effect of systemic PYY3-36 on relapse to food seeking that is independent of Y2 receptor activation in Arc and suggest that PYY3-36 should be considered for the treatment of relapse to maladaptive food-taking habits during dieting. |
| Databáze: | OpenAIRE |
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