Proteomics Analysis of FLT3-ITD Mutation in Acute Myeloid Leukemia Using Deep Learning Neural Network

Autor:	Liang, Christine A., Chen, Lei, Wahed, Amer, Nguyen, Andy N. D.
Rok vydání:	2018
Předmět:	FOS: Computer and information sciences Computer Science - Learning Statistics - Machine Learning FOS: Biological sciences education Machine Learning (stat.ML) Quantitative Biology - Quantitative Methods Quantitative Methods (q-bio.QM) Machine Learning (cs.LG)
DOI:	10.48550/arxiv.1801.01019
Popis:	Deep Learning can significantly benefit cancer proteomics and genomics. In this study, we attempt to determine a set of critical proteins that are associated with the FLT3-ITD mutation in newly-diagnosed acute myeloid leukemia patients. A Deep Learning network consisting of autoencoders forming a hierarchical model from which high-level features are extracted without labeled training data. Dimensional reduction reduced the number of critical proteins from 231 to 20. Deep Learning found an excellent correlation between FLT3-ITD mutation with the levels of these 20 critical proteins (accuracy 97%, sensitivity 90%, specificity 100%). Our Deep Learning network could hone in on 20 proteins with the strongest association with FLT3-ITD. The results of this study allow a novel approach to determine critical protein pathways in the FLT3-ITD mutation, and provide proof-of-concept for an accurate approach to model big data in cancer proteomics and genomics. Comment: 12 pages, 4 figures, 2 tables
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fd9d7e786d30a2a2fdd7a8e231f830 Zobrazit plný text záznamu