Sequential Axon-Derived Signals Couple Target Survival and Layer Specificity in the Drosophila Visual System
| Autor: | Matthew Y. Pecot, C. Kimberly Tsui, S. Lawrence Zipursky, Zhenqing Chen, Orkun Akin, Yi Chen |
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| Rok vydání: | 2014 |
| Předmět: |
Nervous system
Neuroscience(all) Green Fluorescent Proteins Growth Cones Biology Article Animals Genetically Modified Postsynaptic potential Netrin medicine Animals Drosophila Proteins Anaplastic lymphoma kinase Anaplastic Lymphoma Kinase Visual Pathways Axon Receptor Adaptor Proteins Signal Transducing Neurons Budding Cell Death General Neuroscience Receptor Protein-Tyrosine Kinases Axons Lamins Cell biology Luminescent Proteins medicine.anatomical_structure Gene Expression Regulation nervous system Drosophila Photoreceptor Cells Invertebrate Neuron Nerve Net Signal Transduction |
| Zdroj: | Neuron. 82(2):320-333 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2014.02.045 |
| Popis: | Summary Neural circuit formation relies on interactions between axons and cells within the target field. While it is well established that target-derived signals act on axons to regulate circuit assembly, the extent to which axon-derived signals control circuit formation is not known. In the Drosophila visual system, anterograde signals numerically match R1–R6 photoreceptors with their targets by controlling target proliferation and neuronal differentiation. Here we demonstrate that additional axon-derived signals selectively couple target survival with layer specificity. We show that Jelly belly (Jeb) produced by R1–R6 axons interacts with its receptor, anaplastic lymphoma kinase (Alk), on budding dendrites to control survival of L3 neurons, one of three postsynaptic targets. L3 axons then produce Netrin, which regulates the layer-specific targeting of another neuron within the same circuit. We propose that a cascade of axon-derived signals, regulating diverse cellular processes, provides a strategy for coordinating circuit assembly across different regions of the nervous system. |
| Databáze: | OpenAIRE |
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