Automatic Control of the Inspired Oxygen Fraction in Preterm Infants
| Autor: | Christian Popow, Werner Horn, Michael S. Urschitz, Ingo Müller-Hansen, Tina Herberts, Antonella Hallenberger, Silvia Miksch, Christian F. Poets, Andreas Seyfang |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_treatment Positive pressure chemistry.chemical_element Critical Care and Intensive Care Medicine Risk Assessment Oxygen law.invention Positive-Pressure Respiration Automation Oxygen Consumption Randomized controlled trial Reference Values law Intensive care medicine Humans Continuous positive airway pressure Probability Mechanical ventilation Respiratory Distress Syndrome Newborn Cross-Over Studies Pulmonary Gas Exchange business.industry Infant Newborn Oxygen Inhalation Therapy Crossover study Respiratory Function Tests Treatment Outcome chemistry Anesthesia Female Analysis of variance business Infant Premature Follow-Up Studies |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 170:1095-1100 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | In preterm infants receiving supplemental oxygen, manual control of the inspired oxygen fraction is often time-consuming and inappropriate. We developed a system for automatic oxygen control and hypothesized that this system is more effective than routine manual oxygen control in maintaining target arterial oxygen saturation levels. We performed a randomized controlled crossover clinical trial in 12 preterm infants receiving nasal continuous positive airway pressure and supplemental oxygen. Periods with automatic and routine manual oxygen control were compared with periods of optimal control by a fully dedicated person. The median (range) percentage of time with arterial oxygen saturation levels within target range (87-96%) was 81.7% (39.0-99.8) for routine manual oxygen control, 91.0% (41.4-99.3) for optimal control, and 90.5% (59.0-99.4) for automatic control (ANOVA: p = 0.01). Pairwise post hoc comparisons revealed a statistically significant difference between automatic and routine manual oxygen control (Dunnett's test: p = 0.02). The frequency of manual oxygen adjustments was lowest in automatic control (Friedman's test: p < 0.001). Automatic oxygen control may optimize oxygen administration to preterm infants receiving nasal continuous positive airway pressure and reduce nursing time spent with oxygen control. |
| Databáze: | OpenAIRE |
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