Association of Acute Cerebellar Ataxia and Human Papilloma Virus Vaccination: A Case Report
| Autor: | Yoshihiro Maegaki, Susumu Kusunoki, Atsuro Chiba, Ayumi Uchibori, Yuichi Kodama, Hiroshi Hayami, Yukitoshi Takahashi, Chihiro Yonee, Mitsuo Toyoshima, Yoshifumi Kawano |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pediatrics Cerebellar Ataxia Nausea medicine.medical_treatment Vertigo medicine Humans Papillomavirus Vaccines Child Cervical cancer Human papillomavirus 16 biology business.industry Vaccination Plasmapheresis General Medicine biology.organism_classification medicine.disease eye diseases Surgery stomatognathic diseases Treatment Outcome Methylprednisolone Acute Disease Pediatrics Perinatology and Child Health biology.protein Female Neurology (clinical) medicine.symptom Antibody business medicine.drug Truncal ataxia |
| Zdroj: | Neuropediatrics. 44:265-267 |
| ISSN: | 1439-1899 0174-304X |
| DOI: | 10.1055/s-0033-1333873 |
| Popis: | Introduction We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine. Patient and Method This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular rhythm, 12 days after administration of the HPV-16/18 AS04-adjuvanted cervical cancer vaccine. After this, the patient received methylprednisolone pulse and intravenous immunoglobulin (IVIG) therapies as well as immunoadsorption plasmapheresis. Results Severe ACA symptoms did not improve after methylprednisolone pulse and IVIG therapies, but the patient recovered completely after immunoadsorption plasmapheresis. Conclusion This temporal association strongly suggests that ACA was induced by the vaccination. |
| Databáze: | OpenAIRE |
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