PIXSIC: A Pixellated Beta-Microprobe for Kinetic Measurements of Radiotracers on Awake and Freely Moving Small Animals
| Autor: | S. Karkar, Mohsine Menouni, P. Laniece, B. Chantepie, B. Dinkespiler, B. Janvier, F. Lefebvre, P. Pangaud, P. Delpierre, J. C. Clemens, P. Weiss, L. Pinot, M. Jevaud, Jeremy Godart, Frédéric Pain, R. Mastrippolito, Christian Morel |
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| Přispěvatelé: | Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC (UMR_8165)), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), imXgam, Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Nuclear and High Energy Physics
Microprobe Silicon Monte Carlo method freely moving PET imaging chemistry.chemical_element 030218 nuclear medicine & medical imaging silicon pixel detectors wireless measurements 03 medical and health sciences 0302 clinical medicine Optics small animal imaging Beta (velocity) Sensitivity (control systems) Electrical and Electronic Engineering beta microprobe Physics Resistive touchscreen intra-cerebral probe Pixel business.industry [SDV.BA]Life Sciences [q-bio]/Animal biology Detector Anesthesia bias Nuclear Energy and Engineering chemistry [SDV.IB]Life Sciences [q-bio]/Bioengineering business 030217 neurology & neurosurgery |
| Zdroj: | IEEE Transactions on Nuclear Science IEEE Transactions on Nuclear Science, Institute of Electrical and Electronics Engineers, 2010, 57, pp.998-1007. ⟨10.1109/TNS.2010.2044804⟩ IEEE Transactions on Nuclear Science, 2010, 57, pp.998-1007. ⟨10.1109/TNS.2010.2044804⟩ |
| ISSN: | 0018-9499 |
| DOI: | 10.1109/TNS.2010.2044804⟩ |
| Popis: | We present a design study of PIXSIC, a new B^+ radiosensitive microprobe implantable in rodent brain dedicated to in vivo and autonomous measurements of local time activitycurves of beta radiotracers in a small (a few mm^3 ) volume of brain tissue. This project follows the initial β microprobe previously developed at IMNC, which has been validated in several neurobiological experiments. This first prototype has been extensively used on anesthetized animals, but presents some critical limits for utilization on awake and freely moving animals. Consequently, we propose to develop a wireless setup that can be worn by an animal without constraints upon its movements. To that aim, we have chosen a Silicon-based detector, highly β sensitive, which allows for the development of a compact pixellated probe (typically 600 X 200 X1000 μm^3), read out with miniaturized wireless electronics. Using Monte-Carlo simulations, we show that high resistive Silicon pixels are appropriate for this purpose, assuming that the pixel dimensions are adapted to our specific signals. More precisely, a tradeoff has to be found between the sensitivity to β^+ particles and to the 511 keV γ background resulting from annihilations of β^+ with electrons. We demonstrate that pixels with maximized surface and minimized thickness can lead to an optimization of their β^+ sensitivity with a relative transparency to the annihilation background |
| Databáze: | OpenAIRE |
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