Comparing Lavage of the Peritoneal Cavity with Lidocaine, Bupivacaine and Normal Saline to Reduce the Formation of Abdominal Adhesion Bands in Rats
| Autor: | Zahra Farahaninik, Amirhossein Rahmani, Hengameh Saravani, Fatemeh Sameei-Rad, Marjan Nasiri, Hossein Parsa |
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| Rok vydání: | 2015 |
| Předmět: |
Bupivacaine
medicine.medical_specialty Lidocaine business.industry medicine.medical_treatment Adhesion (medicine) General Medicine medicine.disease Abdominal adhesion Surgery 03 medical and health sciences Peritoneal cavity 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Laparotomy Anesthesia medicine 030211 gastroenterology & hepatology Original Article business Saline Abdominal surgery medicine.drug |
| Zdroj: | The Malaysian journal of medical sciences : MJMS. 24(3) |
| ISSN: | 1394-195X |
| Popis: | Background Intra-abdominal adhesions are fibrous bands that develop after abdominal surgery or inflammation and cause mortality and morbidity following surgeries. This study aimed to assess the effects of bupivacaine, saline and two doses of lidocaine, after peritoneal lavage and to compare their effects in reducing abdominal adhesions in rat. Methods In a blinded, randomised, placebo-controlled clinical trial, 50 female rats were anaesthetised and the parietal peritoneum was scratched to induce punctate bleeding. The rats were randomly assigned to five groups: saline, lidocaine 2% (3 and 6 mg/kg), bupivacaine 0.25% (2 mg/kg) and control (no irrigation). The peritoneal cavity was irrigated with the appropriate solution during laparotomy. Two weeks later, re-laparotomy was performed. The quantity, quality, severity and scores of adhesions were recorded and compared. Results The quantity and quality of adhesions were significantly higher in the control group than in the lidocaine (6 mg/kg) and bupivacaine groups. The quality of the adhesions was higher in the normal saline group than in the lidocaine (6 mg/kg) and bupivacaine groups. The severity of adhesions between the lidocaine 3 and 6 mg/kg groups and between the lidocaine 3 mg/kg and saline groups was lower than that in the control group. Conclusion Using lidocaine (6 mg/kg) and bupivacaine lavage in first laparotomy reduces abdominal peritoneal obstruction because of the formation of adhesion bands. |
| Databáze: | OpenAIRE |
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