Occupational exposure to asbestos and risk of cholangiocarcinoma: a population-based case–control study in four Nordic countries

Autor: Stefania Curti, Eero Pukkala, Giovanni Brandi, Elisabete Weiderpass, Pär Sparén, Laufey Tryggvadottir, Kurt Straif, Kristina Kjærheim, Stefano Mattioli, Jan Ivar Martinsen, Andrea Farioli, Francesco Saverio Violante, Guido Biasco
Přispěvatelé: Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, University of Tampere, Farioli, Andrea, Straif, Kurt, Brandi, Giovanni, Curti, Stefania, Kjaerheim, Kristina, Martinsen, Jan Ivar, Sparen, Pär, Tryggvadottir, Laufey, Weiderpass, Elisabete, Biasco, Guido, Violante, Francesco Saverio, Mattioli, Stefano, Pukkala, Eero
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Occupational cancer
Iceland
Cumulative Exposure
medicine.disease_cause
0302 clinical medicine
Risk Factors
Gallrás
Odds Ratio
Terveystiede - Health care science
Workplace
Finland
Aged
80 and over
education.field_of_study
Norway
Middle Aged
030220 oncology & carcinogenesis
Cohort
030211 gastroenterology & hepatology
Female
Asbest
cholangiocarcinoma
Population
cholangiocarcinoma asbestos
Asbestos
NO
03 medical and health sciences
Occupational Exposure
Syöpätaudit - Cancers
medicine
Humans
Risk factor
education
Aged
Krabbamein
Publishing
Sweden
Tilviksrannsóknir
business.industry
Public Health
Environmental and Occupational Health
Case-control study
Odds ratio
medicine.disease
asbestos
Logistic Models
Bile Duct Neoplasms
Case-Control Studies
Vinnuaðstaða
business
cholangiocarcinoma
asbestos
Demography
Zdroj: Occupational and Environmental Medicine
Popis: Objectives To assess the association between occupational exposure to asbestos and the risk of cholangiocarcinoma (CC). Methods We conducted a case–control study nested in the Nordic Occupational Cancer (NOCCA) cohort. We studied 1458 intrahepatic CC (ICC) and 3972 extrahepatic CC (ECC) cases occurring among subjects born in 1920 or later in Finland, Iceland, Norway and Sweden. Each case was individually matched by birth year, gender and country to five population controls. The cumulative exposure to asbestos (measured in fibres (f)/ml × years) was assessed by applying the NOCCA job-exposure matrix to data on occupations collected during national population censuses (conducted in 1960, 1970, 1980/81 and 1990). Odds ratios (OR) and 95% CI were estimated using conditional logistic regression models adjusted by printing industry work. Results We observed an increasing risk of ICC with cumulative exposure to asbestos: never exposed, OR 1.0 (reference category); 0.1–4.9 f/mL × years, OR 1.1 (95% CI 0.9 to 1.3); 5.0–9.9 f/mL × years, OR 1.3 (95% CI 0.9 to 2.1); 10.0–14.9 f/mL × years, OR 1.6 (95% CI 1.0 to 2.5); ≥15.0 f/mL × years, OR 1.7 (95% CI 1.1 to 2.6). We did not observe an association between cumulative asbestos exposure and ECC. Conclusions Our study provides evidence that exposure to asbestos might be a risk factor for ICC. Our findings also suggest that the association between ECC and asbestos is null or weaker than that observed for ICC. Further studies based on large industrial cohorts of asbestos workers and possibly accounting for personal characteristics and clinical history are needed.
Nordic Cancer Union funded the NOCCA project. The work by AF, GBr, SC, GBi, FSV and SM was partially supported by internal funds of the Department of Medical and Surgical Sciences and the Department of Experimental, Diagnostic, and Specialty Medicine of the University of Bologna.
Databáze: OpenAIRE
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