Exercise-Induced Changes in Plasma Atrial Natriuretic Peptide and Brain Natriuretic Peptide Concentrations in Healthy Subjects With Chronic Sleep Deprivation

Autor: Haruki Itoh, Noriyuki Suzuki, Hisanori Samejima, Misa Oya, Kazuto Omiya, Kazuhiko Tanabe, Masahiro Murayama, Naohiko Osada, Masaru Nakayama, Atsushi Seki, Fumihiko Miyake, Yoshihiro J. Akashi, Taizo Murabayashi, Yasuhiro Yokoyama, Akiko Yamamoto
Rok vydání: 1999
Předmět:
Zdroj: Japanese Circulation Journal. 63:447-452
ISSN: 1347-4839
0047-1828
Popis: Recent observations have shown that plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) correlate with cardiac function or prognosis in heart failure patients. However, relatively little is known about changes in their plasma concentration during commonly occurring physiological states such as fatigue. Therefore, this study was designed to examine the physiological changes of plasma ANP and BNP concentrations using a chronic sleep-deprivation model. Bicycle ergometer cardiopulmonary exercise tests were performed in 10 healthy volunteers (mean age: 22.7 years). Blood samples for measuring ANP and BNP were drawn during the resting state and immediately after each exercise test. Cardiac output (CO) was measured during the exercise test by the impedance method. The study conditions were designed as follows: (A) a day following a period of normal sleep (control state) and (B) a day preceded by 1 month during which sleep lasted
Databáze: OpenAIRE