Health-related quality of life assessment in prospective trials of systemic cytotoxic chemotherapy for metastatic castration-resistant prostate cancer: which instrument we need?
Autor: | Pasquale Colloca, Giuseppe A Colloca |
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Přispěvatelé: | Colloca G., Colloca P. |
Rok vydání: | 2010 |
Předmět: |
Male
Cancer Research medicine.medical_specialty psychological health Alternative medicine MEDLINE Antineoplastic Agents Severity of Illness Index law.invention Prostate cancer Cost of Illness Randomized controlled trial Quality of life law Surveys and Questionnaires Severity of illness medicine Humans Clinical significance Intensive care medicine Randomized Controlled Trials as Topic business.industry Prostatic Neoplasms Hematology General Medicine medicine.disease humanities Clinical trial Clinical Trials Phase III as Topic Oncology Quality of Life Physical therapy business |
Zdroj: | Medical Oncology. 28:519-527 |
ISSN: | 1559-131X 1357-0560 |
Popis: | Knowledge about psychological health of men with prostate cancer is still limited. HRQoL assessment adds value in symptom management by allowing a broader understanding of the impact of symptom management beyond the targeted symptom, on functioning, and on overall QoL. In this paper, the results of the commonly used HRQoL questionnaires in phase III randomized clinical trials of chemotherapy in metastatic castration-resistant prostate cancer has been discussed. An overview about symptom burden, treatments and HRQoL domains, a description of available HRQoL instruments used for patients with metastatic castration-resistant prostate cancer were reported. Finally, the characteristics of most commonly used HRQoL instruments were identified and compared. To provide better empirical justification for the selection of HRQoL instruments, head-to-head comparisons of them within the same studies are needed. Estimating a minimal important difference could be significant when interpreting trial results. The impact of HRQoL scores in clinical practice remains unclear; poor communication of clinical significance of the results and limited training of clinicians are the most important barriers to a widespread use of HRQoL questionnaires. |
Databáze: | OpenAIRE |
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