IgM, not IgG, a key for HIV vaccine
| Autor: | Quan-en Yang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
AIDS Vaccines
Cellular immunity General Veterinary General Immunology and Microbiology Viral Vaccine Public Health Environmental and Occupational Health HIV Infections Viral Vaccines Disease Biology Virology Virus Immunoglobulin G Infectious Diseases Immune system HIV Antigens Immunoglobulin M Drug Design Immunology Antibody Formation biology.protein Molecular Medicine Humans HIV vaccine |
| Zdroj: | Vaccine. 27(9) |
| ISSN: | 0264-410X |
| Popis: | Although HIV infections induce a very strong humoral immune reaction with various neutralization activities and a well-defined cellular immunity, HIV vaccine development based on traditional approaches failed. The fact that neither specific antibodies nor activated CD8+ cytotoxicity T-cells could provide primary protection in high risk populations raises the question concerning whether a specific vaccine is feasible. While the immune system as an intact defense system against HIV is ineffective or may even enhance the virus spread, a distinct small part of the system plays important role in delaying the progress of the disease. After carefully dissecting the different immune reactions against the virus, a new HIV vaccine strategy is indicated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect