Cucurbita maxima (Pumpkin) seeds: Scolicidal activity and preventive efficacy of its extract on experimental hydatidosis in mice
| Autor: | Mohammad Asadpour, Arash Babaei, Arash Jafari, Morteza Shamsi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Preventive assay
Group ii lcsh:Medicine Hydatid cyst Albendazole 03 medical and health sciences 0302 clinical medicine food In vivo parasitic diseases Medicine Helminths Inhibitory effect Scolicidal lcsh:R5-920 Pumpkin seed biology Traditional medicine business.industry lcsh:R biology.organism_classification Hydatid disease food.food 030220 oncology & carcinogenesis Cucurbita maxima methanolic extracts 030211 gastroenterology & hepatology lcsh:Medicine (General) business Cucurbita maxima medicine.drug |
| Zdroj: | Journal of Basic Research in Medical Sciences, Vol 5, Iss 1, Pp 22-28 (2018) |
| ISSN: | 2383-0972 2383-0506 |
| DOI: | 10.29252/jbrms.5.1.22 |
| Popis: | Introduction: Hydatid Disease (HD), a helminth infection with various clinical complications is a serious economic and public health concern around the world. Nowadays, different agents have been broadly applied as scolicids; these agents have several side effects on patients. Therefore, the aims of this experimental study were to evaluate the scolicidal activity of Cucurbita maxima seeds methanolic extract (ME) against protoscolices of hydatid cyst in-vitro. Also, an in vivo assay was designed to prove the preventive effects of the extract. Materials and methods: For this work, Two different concentrations (25 and 50 mg/ml) of the C. maxima seeds ME were used in various exposure times (10, 20, 30, 40, 50, and 60 min). Additionally, thirty mice were infected intraperitoneally by injection of 1000 viable protoscolices and were divided into three groups with ten mice in each Group I (treated by Albendazole), group II (received 50 mg/ml of C. maxima seeds ME) and group III (untreated controls). Results: Overall, C. maxima seeds ME exhibited significant scolicidal effects in compared with control group (P |
| Databáze: | OpenAIRE |
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