The effect of medroxyprogesterone acetate, administered to the lactating rat, on the subsequent growth, maturation and reproductive function of the litter
| Autor: | M. Tankeyoon, N. Satayasthit, R. R. Chaudhury |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Litter (animal)
Medroxyprogesterone Embryology medicine.medical_specialty media_common.quotation_subject Population Endocrinology Pregnancy Internal medicine Lactation Animals Medicine Medroxyprogesterone acetate Sexual Maturation education media_common Estrous cycle education.field_of_study business.industry Reproduction Obstetrics and Gynecology Cell Biology medicine.disease Rats medicine.anatomical_structure Animals Newborn Reproductive Medicine Female business Sex ratio medicine.drug |
| Zdroj: | Reproduction. 46:411-412 |
| ISSN: | 1741-7899 1470-1626 |
| DOI: | 10.1530/jrf.0.0460411 |
| Popis: | The possible action of medroxyprogesterone acetate (MPA) in increasing milk secretion when administered to lactating women has led to the speculation that it could be used more for contraception during lactation. Studies were carried out on control and experimental female and male young rats. The experimental rats were given 5 mcg MPA. Differences in the growth rates of the control and experimental young on Day 60 were absent. All experimental rats became pregnant; abnormalities were absent at birth and sex ratio was normal. Deficiencies in the lactational performance growth curves and weight curves of young male and female control and experimental animals were absent. Treatment of lactating females with MPA did however significantly delay the onset of vaginal opening and 1st estrous cycle in the young. The significance of this finding is under investigation. |
| Databáze: | OpenAIRE |
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